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In vitro, the use of 3D multicellular co-culture models allow for a physiologically relevant cellular arrangement and the exchange of intracellular components such as protein, RNA and DNA. 45 The release of extracellular vesicles (EVs) by neighbouring cells is one such cellular exchange system shown to be a key regulator of endothelial function and dysfunction. 46 Some emerging evidence now

Endothelial dysfunction has been shown to be of significance in predicting stroke and heart attacks due to the inability of the arteries to dilate fully. The dysfunction may be a result of high blood pressure, diabetes, high cholesterol and smoking. Endothelial dysfunction is characterized by a reduction of the bioavailability of vasodilators, in particular, nitric oxide (NO), whereas endothelium-derived contracting factors are increased. 3 This imbalance leads to an impairment of endothelium-dependent vasodilation, which represents the functional characteristic of endothelial dysfunction.

Page 2. 120. 18. nov 2019 Endotelial dysfunksjon er når endotelcellelaget på innsiden av blodåreveggen ikke fungerer som normalt.

3 Results for All Collections · Endothelfunktion bei kardialen Erkrankungen unter Berücksichtigung immunologischer Prozesse : Endothelial Dysfunction in Cardiac

Endothelial barrier dysfunction in cancer. Bakgrund.

Abnormal vasomotor response is a sign of endothelial dysfunction and a prognostic factor for adverse cardiac events (17). The consequences of endothelial dysfunction might go beyond the induction of coronary vasospasm because the endothelium secretes anti-thrombotic substances, such as prostacyclin or tissue plasminogen activators.

Endothelial Dysfunction. Endothelial dysfunction is a systemic pathological condition which can be broadly defined as an imbalance between vasodilating and vasoconstricting substances produced by the endothelium or overall functions of the endothelium [].Normal functions of endothelial cells include production of nitric oxide (NO), regulation of platelet adhesion, coagulation, immune 2009-11-01 2017-04-03 Actually, endothelial dysfunction itself, mirrored by hyper-in ammation could cause alterations of the coagulation thereby aggravating the prognosis of the disease (2,3). Furthermore, folate restored endothelial dysfunction during a methionine load test in healthy volunteers without affecting the rise in plasma homocysteine levels (Usui et al., 1999). In STZ‐diabetes in the rat, folate acutely improved endothelial dysfunction in the renal microcirculation (De Vriese et al., 1999). Given the relationship between endothelial dysfunction and potential mechanisms of brain dysfunction during critical illness, we hypothesized that critically ill patients with systemic vascular endothelial dysfunction would be at greater risk for acute brain dysfunction ().To test this hypothesis, we assessed endothelial function via a reactive hyperemia technique with peripheral artery 230 Endothelial Dysfunction, Hemodynamic Forces, and Atherogenesisa MICHAEL A. GIMBRONE, JR.,b JAMES N. TOPPER,c TOBI NAGEL,d KEITH R. ANDERSON, AND GUILLERMO GARCIA-CARDEÑA Vascular Research Division, Department of Pathology, Brigham and Women’s Hospital 2004-10-01 2018-08-31 Endothelial dysfunction:: Compromise of normal function of endothelial cells leading to the inability of arteries and arterioles to dilate fully in response to an appropriate stimulus; strongly associated with hypertension, hypercholesterolaemia, diabetes, smoking tobacco, etc; a key event in the development of atherosclerosis, predating 2018-10-30 Title:Experimental and Clinical Evidence of Endothelial Dysfunction in Inflammatory Bowel Disease VOLUME: 26 ISSUE: 30 Author(s):Mariana Ferreira-Duarte, Joana Beatriz Sousa, Carmen Diniz, Teresa Sousa, Margarida Duarte-Araújo and Manuela Morato* Affiliation:LAQV@REQUIMTE, University of Porto, Porto, LAQV@REQUIMTE, University of Porto, Porto, LAQV@REQUIMTE, University of Porto, Porto Endothelial dysfunction has been postulated to represent an initial step in the pathogenesis of atherosclerosis in the general population [].Accordingly, efforts to elucidate unique mechanisms driving increased cardiovascular risk in patients with inflammatory diseases have often focused on the endothelium, which serves as an interface for multiple converging risk factors.

av JC McGrath · 2009 · Citerat av 1 — (2009). Increased endothelin-1 reactivity and endothelial dysfunction in carotid arteries from rats with hyperhomocysteine- mia. Br J Pharmacol 157: 568–580.
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Endocr Rev, 22: 36-52 [39] Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M,et al. (2001). Mechanisms underlying endothelial dysfunction in diabetes mellitus.

Actually, endothelial dysfunction itself, mirrored by hyper-in ammation could cause alterations of the coagulation thereby aggravating the prognosis of the disease (2,3).
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A feature of endothelial dysfunction is the inability of arteries and arterioles to dilate fully in response to an appropriate stimulus, such as exogenous nitroglycerine,

Endothelial dysfunction in chronic obstructive pulmonary disease. Moro L(1), Pedone C, Scarlata S, Malafarina V, Fimognari F, Antonelli-Incalzi R. Author information: (1)Area di Geriatria, Università Campus Biomedico, Rome, Italy. l.moro@unicampus.it Endothelial dysfunction, which is a constant condition, alone would probably not explain the sudden occurrence of ≥90% vasoconstriction during coronary spasm provocation test (corresponding to the definition of epicardial CAS according to the Japanese Circulation Society guidelines) with concomitant reproduction of their usual symptoms at home.

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Endothelial dysfunction, which is a constant condition, alone would probably not explain the sudden occurrence of ≥90% vasoconstriction during coronary spasm provocation test (corresponding to the definition of epicardial CAS according to the Japanese Circulation Society guidelines) with concomitant reproduction of their usual symptoms at home. 5 However, the presence of VSMC hyperreactivity

Endothelial dysfunction is a term that refers to impaired functioning of the lining of blood vessels. It is characterized by: impaired vasodilation; deficiency of nitric oxide; an "activated endothelium" that is in a state of inflammation, growth, and thrombosis (blood clotting) Endothelial dysfunction is a type of non-obstructive coronary artery disease (CAD) in which there are no heart artery blockages, but the large blood vessels on the heart’s surface constrict (narrow) instead of dilating (opening). This condition tends to affect more women than men and causes chronic chest pain. Endothelial dysfunction is a major driver of heart disease and involves an inability of the endothelium to regulate blood pressure. 2010-10-01 · Endothelial dysfunction can be regarded as a syndrome whose systemic manifestations are associated with significant morbidity and mortality. The concept of endothelial dysfunction should be extended beyond conduit vessels to the vascular wall, and perhaps also to bone marrow and progenitor endothelial cells.